Evolution-guided protein design of IscB for persistent epigenome editing in vivo

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In: Science & Nature

Main Natural programmable enzymes have transformed our ability to study and treat complex diseases. The application and engineering of RNA-guided systems, most notably clustered regularly interspaced short palindromic repeats (CRISPR)–Cas9, has accelerated genetic screening methods to discover the genetic basis of diseases, enabled the generation of precision cellular and animalContinue Reading