Site-specific drug release of monomethyl fumarate to treat oxidative stress disorders

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In: Science & Nature

Main The transcription factor nuclear factor E2-related factor 2 (NRF2) is an attractive therapeutic target because its activation stimulates a panoply of antioxidants that naturally resolve oxidative stress, a process central to diseases with great societal burden1,2,3,4. However, systemically distributed activators such as monomethyl fumarate (MMF) have global on-target actionsContinue Reading