DIF Microscopy Helps Diagnose Pediatric Skin Diseases

TOPLINE: Direct immunofluorescence (DIF) microscopy showed a 15.5% positivity rate in pediatric patients and changed the clinical diagnosis in 16.7% of those cases. METHODOLOGY: Researchers conducted a retrospective review of DIF data from 986 patients aged 0-18 years (mean age, 12 years) at the Mayo Clinic’s reference immunodermatology laboratory betweenContinue Reading

Which Tx Combo Is Best for HER2+ Breast Cancer?

The combination of trastuzumab deruxtecan (Enhertu) with pertuzumab (Perjeta) as a first-line treatment for HER2-positive advanced metastatic breast cancer has been shown to reduce the risk for disease progression or death by more than the current standard-of-care treatment. Sara Tolaney, MD, MPH Sara Tolaney, MD, MPH, of the Dana-Farber CancerContinue Reading

IL-23 Inhibitors Show Highest Drug Survival in Psoriasis

TOPLINE: Interleukin (IL)-23p19 inhibitors guselkumab and risankizumab demonstrated the highest drug survival for effectiveness and safety comparable with ustekinumab over 2 years, exceeding that of all other biologics. IL-17 receptor inhibitor brodalumab showed comparable effectiveness and safety with adalimumab and secukinumab. METHODOLOGY: Researchers conducted a cohort study using data fromContinue Reading