Which Tx Combo Is Best for HER2+ Breast Cancer?

The combination of trastuzumab deruxtecan (Enhertu) with pertuzumab (Perjeta) as a first-line treatment for HER2-positive advanced metastatic breast cancer has been shown to reduce the risk for disease progression or death by more than the current standard-of-care treatment. Sara Tolaney, MD, MPH Sara Tolaney, MD, MPH, of the Dana-Farber CancerContinue Reading

IL-23 Inhibitors Show Highest Drug Survival in Psoriasis

TOPLINE: Interleukin (IL)-23p19 inhibitors guselkumab and risankizumab demonstrated the highest drug survival for effectiveness and safety comparable with ustekinumab over 2 years, exceeding that of all other biologics. IL-17 receptor inhibitor brodalumab showed comparable effectiveness and safety with adalimumab and secukinumab. METHODOLOGY: Researchers conducted a cohort study using data fromContinue Reading

Tracking Triptan Safety During Pregnancy

TOPLINE: Prenatal exposure to triptans, alone or with other migraine medications, was not associated with a significantly increased risk for neurodevelopmental disorders (NDDs) in children born to mothers with a history of migraine in a new study. METHODOLOGY: Researchers conducted a registry-based cohort study in Norway, using data from multipleContinue Reading