Evolution-guided protein design of IscB for persistent epigenome editing in vivo

Main Natural programmable enzymes have transformed our ability to study and treat complex diseases. The application and engineering of RNA-guided systems, most notably clustered regularly interspaced short palindromic repeats (CRISPR)–Cas9, has accelerated genetic screening methods to discover the genetic basis of diseases, enabled the generation of precision cellular and animalContinue Reading

10 beautiful images from the 2025 GDT Nature Photographer of the Year awards

“Anybody home?” A curious young lion plays with a tortoise in the Kalahari Desert, Botswana.   Credit: Jens Cullmann  Get the Popular Science daily newsletter💡 “It’s been over two decades since I first witnessed a dipper darting through a waterfall,” photographer Konrad Wothe says. “The small passerine bird was flyingContinue Reading

Mathematician solves algebra’s oldest problem

Polynomials were first conceived by the Babylonians around 1800 BCE. Credit: Getty Images Get the Popular Science daily newsletter💡 Most people’s experiences with polynomial equations don’t extend much further than high school algebra and the quadratic formula. Still, these numeric puzzles remain a foundational component of everything from calculating planetaryContinue Reading

Future planets revealed in unprecedented detail

Deep ALMA observations of 12CO emission from fifteen protoplanetary disks reveal a stunning range of structures in the gas morphology including gaps, rings and spirals. Credit: Richard Teague / exoALMA Collaboration Get the Popular Science daily newsletter💡 Our solar system is approximately 4.6 billion years old, but countless planetary neighborhoodsContinue Reading