AAV capsid prioritization in normal and steatotic human livers maintained by machine perfusion

Main Adeno-associated virus (AAV) vectors proved to be effective and safe for hepatocyte-targeted reversal of factor IX and VIII deficiency in hemophilia B and A, respectively, with the AAV5 capsid being the first to receive Food and Drug Administration (FDA) approval1,2. However, these achievements of therapeutic efficacy cannot be readilyContinue Reading

CoStar, TE Slightly Adjust Growth Projections in First U.S. Hotel Forecast of 2025

WASHINGTON—CoStar and Tourism Economics made minimal adjustments to growth projections in the first U.S. hotel forecast of 2025 released at the Americas Lodging Investment Summit (ALIS). For 2025, projected gains in average daily rate (ADR) and revenue per available room (RevPAR) were unchanged from the previous forecast, +1.6 percent andContinue Reading

Mike Deitemeyer Joins the Rockbridge Holdings Team

Mike Deitemeyer joined Rockbridge as executive vice president of Rockbridge Holdings and president of its development company. As the company looks to scale and grow in the luxury and lifestyle segment, Deitemeyer will lead strategic affiliates beginning with its newest acquisition, ZaZa Hotels and Resorts. With a background spanning operations,Continue Reading

Mercedes-Benz Fires 20,000 Employees

Mercedes is set to lay off tens of thousands of employees as part of a restructuring to respond to market conditions. Following Volkswagen’s announcement of over 30,000 job cuts, the German automotive sector is facing challenges that have also affected other leading manufacturers. Reports indicate that Mercedes is considering layingContinue Reading

Why ‘Bidenomics’ Isn’t Working For Biden

Welcome to FiveThirtyEight’s politics chat. The transcript below has been lightly edited. nrakich (Nathaniel Rakich, senior elections analyst): For a long time, the economy has been seen as a big liability for President Biden in his reelection bid. Inflation soared in 2021 and 2022, culminating at a rate of 9.1Continue Reading