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The Ole Miss Rebels return home this week riding high after a statement win over Oklahoma, ready to host the South Carolina Gamecocks in a pivotal SEC showdown. With the Rebels favored by 12.5 points, Lane Kiffin’s squad looks to keep its offensive momentum rolling against a South Carolina team still reeling from a heartbreaking loss to Alabama.
Both programs enter with something to prove, as Ole Miss aims to solidify its standing as a conference contender and South Carolina seeks to regroup and pull off an upset on the road. The South Carolina vs. Ole Miss prediction provides a breakdown of the key storylines, grades, and insights as both teams prepare for this high-stakes matchup.
South Carolina vs. Ole Miss Details
- Date: Saturday, Nov. 1, 2025
- Game time: 7 p.m. EST
- Location: Vaught-Hemingway Stadium | Oxford, MS
- Predicted weather at kick: 57 degrees, chance of showers
- How to watch: ESPN
South Carolina vs. Ole Miss Head-to-Head Record
The football rivalry between South Carolina and Ole Miss dates back to 1947, with the two teams having faced off 18 times since their first meeting. Ole Miss holds a slight edge in the all-time series, winning 10 games compared to South Carolina’s 8. The matchup has been historically competitive, with momentum shifting between the programs over the decades.
Ole Miss claimed the largest victory in the series during their inaugural meeting, shutting out South Carolina 33-0 in 1947. The Rebels also hold the longest winning streak, defeating the Gamecocks five consecutive times between 1981 and 2004. South Carolina has enjoyed its own stretches of success, particularly during the 2000s under coach Steve Spurrier.
In recent years, Ole Miss has regained control, winning six of the last nine meetings, including a dominant 27–3 victory in Columbia in 2024 and a memorable 59–42 shootout win in 2020. Games played in Columbia have typically been more balanced, showing that home-field advantage has played a role in keeping the series competitive.
Overall, the South Carolina vs. Ole Miss football series is a spirited matchup marked by alternating periods of dominance and close contests. The South Carolina vs. Ole Miss prediction highlights a rivalry that continues to captivate fans with its tradition and intensity.
South Carolina vs. Ole Miss Grades
- Ole Miss: 87.5 (B+)
- South Carolina: 75.7 (C)
- Ole Miss: 79.7 (C+)
- South Carolina: 80.5 (B-)
- Ole Miss: 83.4 (B)
- South Carolina: 66.2 (D)
- Ole Miss: Trinidad Chambliss 86.6 (B)
- South Carolina: LaNorris Sellers 79.6 (C+)
- Ole Miss: Kewan Lacy 86.2 (B)
- South Carolina: Rahsul Faison 70 (C-)
- Ole Miss: Harrison Wallace 78.4 (C+)
- South Carolina: Vandrevius Jacobs 77.4 (C+)
- Ole Miss: Dae’Quan Wright 83.8 (B)
- South Carolina: Brady Hunt 75.2 (C)
- Ole Miss: Kam Franklin 78 (C+)
- South Carolina: Dylan Stewart 82 (B-)
- Ole Miss: Will Echoles 81.3 (B-)
- South Carolina: Monkell Goodwine 75.1 (C)
- Ole Miss: TJ Dottery 76.2 (C)
- South Carolina: Fred Johnson 75 (C)
- Ole Miss: Antonio Kite 82.3 (B-)
- South Carolina: Brandon Cisse 87.7 (B+)
- Ole Miss: Wydett Williams Jr. 87.2 (B+)
- South Carolina: Peyton Williams 80.9 (B-)
South Carolina vs. Ole Miss Prediction
The upcoming matchup between Ole Miss and South Carolina sets up as a pivotal SEC contest, with the Rebels entering as 12.5-point favorites at home.
Ole Miss is coming off a statement win over Oklahoma, where they showcased one of their most balanced performances of the season, having the offense firing on all cylinders against a strong Sooner defense, and the defense holding firm against a high-powered attack. South Carolina, on the other hand, is looking to bounce back after a heartbreaking loss to top-ranked Alabama, where they let a late lead slip away.
Statistically, Ole Miss holds a clear edge on both sides of the ball. The Rebels are averaging 37.0 points per game, ranking 19th nationally, and moving the ball efficiently with 484.3 total yards per game.
Quarterback Trinidad Chambliss has been a steady leader under center with 1,864 passing yards and nine touchdowns, while Kewan Lacy provides balance on the ground with nearly 700 rushing yards. Harrison Wallace III has emerged as the go-to target in the passing game, and the defense, led by T.J. Dudley and pass rusher Princewill Umanmielen, has been an opportunistic crew showing bend but less break as a unit.
South Carolina’s challenge will be finding consistent offense against a confident Ole Miss defense. The Gamecocks have struggled to generate big plays, averaging only 20.4 points per game and 302.1 total yards. Quarterback LaNorris Sellers has shown flashes of promise but has faced heavy pressure behind an inconsistent offensive line. Slowing Sellers down is the key factor for Ole Miss since he oozes the potential to dominate any given game.
Running back Rahsul Faison and receiver Vandrevius Jacobs will need big performances to keep the Rebels’ defense honest. The Rebels’ biggest weakness is their defense, especially their run defense, and the Gamecocks will want to exploit that.
Defensively, South Carolina remains solid, allowing just 21.1 points per game, with DQ Smith and Bryan Thomas Jr. anchoring a unit that plays with toughness but has been tested by stronger offenses. Also, watch out for their stud EDGE rusher Dylan Stewart to wreak havoc and make Chambliss’ day a long one on Saturday night.
Given the numbers and momentum, Ole Miss enters this matchup in control. Their offensive balance, home-field advantage, and defensive depth give them a strong edge over a South Carolina team that continues to search for rhythm.
Anything can happen in the SEC, but I expect Ole Miss to stay focused as they are close to locking in a potential CFP appearance with each win they get from here on out. Unless the Gamecocks can slow the Rebels’ pace and win the turnover battle, Ole Miss is poised to cover the spread and secure another convincing conference victory.
Prediction: Ole Miss 35, South Carolina 20
