Structural basis of excitatory amino acid transporter 3 substrate recognition

Proceedings of the National Academy of Sciences, Volume 122, Issue 16, April 2025.
SignificanceHuman excitatory amino acid transporter 3 (EAAT3) pumps L-glutamate, L-aspartate, and L-cysteine into cells using ion gradients. Its dysfunction is associated with neurological pathologies, and it is activated in cancers. Here, we examine the …
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